The Efficacy of High Dose of Cold Physical Plasma on Healing Process of Skin Wounds

Abstract

The goal of the research is to evaluate the effectiveness of a physical plasma device in treating skin wounds in dogs, and to study the differences in the effects of plasma radiation. Also, the significance of the research is the use of the latest scientific methods and cast iron, and the impact of cold plasma physics on virtually no public health outcomes, is used to cover special cases, representing 99% of the universe. The study has adopted the descriptive analytical approach to study the research problem to reach results and solutions.

As well as, evaluations for clinical, histopathological and biochemical test evaluations were based on the changes of treated wounds in response to cold physical plasma treated compared to control group. Helium plasma jet in this research, was used two different operating condition (plasma power density and dose) that meets medical requirements. The results showed the presence of reactive nitrogen and reactive oxygen species in the emission line spectrum as well the operating conditions were: a flow rate of (6 slm or 10 slm) with a temperature of (32 °C or 40 °C) respectively. In addition, Clinical observations revealed early and complete closure of plasma-treated wounds of different doses in comparison with control group. Also, the results of the histopathological scoring were in inflammatory infiltration between groups represented by increased inflammation in treatment groups (A& B) than control group (C) with significant difference (P<0.001), and biochemical observation revealed no toxic effect appear in blood samples used in test during experiment period (3,7 and 21) days. As, conclusions, the operating conditions used were regarded as safe for biomedical applications and accelerating the healing process in skin wounds.